International Journal of Nanoscience and Nanotechnology

International Journal of Nanoscience and Nanotechnology

Coal Tar Pitch / Graphene / Polyglycine Modified Pencil Graphite Electrode for Simultaneous Electrochemical Detection of Guanine and Adenine

Document Type : Research Paper

Authors
Şeyma Korkmaz 1
Nesim İslamoğlu 1
Ecir Yılmaz 2
Zafer Üstündağ 3
İbrahim Ender Mülazımoğlu 2
Ayşen Demir Mülazımoğlu 2
1 Chemistry Department, Institute of Science, Necmettin Erbakan University, Konya, Turkey
2 Chemistry Department, Ahmet Keleşoğlu education Faculty, Necmettin Erbakan University, Konya, Turkey
3 Chemistry Department, Science and Art Faculty, Dumlupınar University, Kütahya, Turkey
10.22034/ijnn.2025.2014213.2446
Abstract
   In this study, a coal tar pitch / graphene / polyglycine modified pencil graphite electrode sensor was developed for the quantitative detection of guanine and adenine, two of the most important components of DNA and RNA. Therefore, the determination of guanine and adenine is of great significance. The coal tar pitch / graphene / polyglycine modified pencil graphite electrode was characterized by scanning electron microscope. Cyclic voltammetry, electrochemical impedance spectroscopy, linear sweep voltammetry, and square wave voltammetry techniques were employed to analyze the behavior of guanine and adenine on coal tar pitch/ graphene/ polyglycine modified pencil graphite electrode in 0.1 M of H2SO4. Under the optimal conditions, electrical signals were linear over the concentration ranges from 1.0 to 25 μM and 10.0 to 140 μM for simultaneous determination of guanine and adenine with the detection limit as low as 0.6 μM and 6 μM, respectively. As a candidate for developing electrochemical sensors, the coal tar pitch/ graphene/ polyglycine modified pencil graphite electrode sensor presented here has a wide range of potential applications.
Keywords
Adenine
Guanine
Cyclic voltammetry
Square wave voltammetry
Pencil graphite electrode
Polyglycine
Subjects
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International Journal of Nanoscience and Nanotechnology
Volume 20, Issue 3
2024
Pages 171-183