Selective Potentiometric Sensor for Isoniazid Ultra-Trace Determination Based on Fe3O4 Nanoparticles Modified Carbon Paste Electrode (Fe3O4/CPE)

Document Type : Research Paper


1 Department of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran.

2 Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran.


   Significant effects of magnetic iron oxide (Fe3O4) nanoparticles on the potentiometric behavior of carbon paste electrode for bio determination of Isoniazid aromatic drug (INH) were studied. The electrochemical performance of modified Fe3O4/CPE was investigated. The constructed Fe3O4/CPE showed high precision, sensitivity and selectivity, for successfully determination of ultra-trace concentration of INH samples. In this research, pH effects, optimal condition for electrode and interfering Ions, on electrode response were investigated. The best potential response for Fe3O4/CPE was obtained with electrode composition of 0.012 g magnetic NPs, 0.006 g silicon oil and 0.060 g graphite powder at pH 6.5 and showed such a low detection limit as 3.09×10−13 mol L−1 INH.