Efficient Synthesis of 2, 3-Dihydroquinazolin-4(1H)-ones in the Presence of Ferrite/Chitosan as a Green and Reusable Nanocatalyst

Document Type: Research Paper


Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran


In this work, an efficient and facile method has been developed for the synthesis of 2,3-
dihydroquinazolin-4(1H)-ones from a condensation reaction of 2-aminobenzamide with various alkyl,
aryl and alicyclic aldehydes or ketones using Fe
3O4/chitosan as an environmentally benign, magnetically
recoverable nanocomposite catalyst in ethanol at room temperature in high to excellent yields under
mild reaction conditions. The Fe
3O4/chitosan composite nanocatalyst was first prepared by a sol-gel
method and characterized by using a variety of conventional techniques including Fourier transforms
infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) and
X-ray diffraction (XRD) analyses. The present work include several advantages such as avoiding the use
of toxic solvents or expensive catalysts, generality, high yields, short reaction times, clean reaction
profile, ease of product isolation, simplicity, recyclability of the catalyst and finally agreement with the
green chemistry protocols. All make it a useful and attractive protocol for the synthesis of heterocyclic
compounds like quinazolinone derivatives.