• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Staff
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter Telegram
International Journal of Nanoscience and Nanotechnology
Articles in Press
Current Issue
Journal Archive
Volume Volume 14 (2018)
Volume Volume 13 (2017)
Volume Volume 12 (2016)
Volume Volume 11 (2015)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 10 (2014)
Volume Volume 9 (2013)
Volume Volume 8 (2012)
Volume Volume 7 (2011)
Volume Volume 6 (2010)
Volume Volume 5 (2009)
Volume Volume 4 (2008)
Volume Volume 3 (2007)
Mohamadnia, Z., Ahmadi, E., Ghasemnejad, M., Hashemikia, S., Doustgani, A. (2015). Surface Modification of Mesoporous Nanosilica with [3-(2-Aminoethylamino) propyl] Trimethoxysilane and Its Application in Drug Delivery. International Journal of Nanoscience and Nanotechnology, 11(3), 167-177.
Z. Mohamadnia; E. Ahmadi; M. Ghasemnejad; S. Hashemikia; A. Doustgani. "Surface Modification of Mesoporous Nanosilica with [3-(2-Aminoethylamino) propyl] Trimethoxysilane and Its Application in Drug Delivery". International Journal of Nanoscience and Nanotechnology, 11, 3, 2015, 167-177.
Mohamadnia, Z., Ahmadi, E., Ghasemnejad, M., Hashemikia, S., Doustgani, A. (2015). 'Surface Modification of Mesoporous Nanosilica with [3-(2-Aminoethylamino) propyl] Trimethoxysilane and Its Application in Drug Delivery', International Journal of Nanoscience and Nanotechnology, 11(3), pp. 167-177.
Mohamadnia, Z., Ahmadi, E., Ghasemnejad, M., Hashemikia, S., Doustgani, A. Surface Modification of Mesoporous Nanosilica with [3-(2-Aminoethylamino) propyl] Trimethoxysilane and Its Application in Drug Delivery. International Journal of Nanoscience and Nanotechnology, 2015; 11(3): 167-177.

Surface Modification of Mesoporous Nanosilica with [3-(2-Aminoethylamino) propyl] Trimethoxysilane and Its Application in Drug Delivery

Article 4, Volume 11, Issue 3, Summer 2015, Page 167-177  XML PDF (912 K)
Document Type: Research Paper
Authors
Z. Mohamadnia* 1; E. Ahmadi2; M. Ghasemnejad2; S. Hashemikia3; A. Doustgani4
1Department of chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava zang, Zanjan, I. R. Iran
2Department of chemistry, University of Zanjan, Zanjan, I. R. Iran.
3Department of Textile Engineering, Center of Excellence in Textile, Amirkabir University of Technology (Tehran Polytechnic), Tehran, I. R. Iran.
4Department of chemistry, University of Zanjan, Zanjan, I. R. Iran., Department of Chemical Engineering, University of Zanjan, Zanjan, Iran
Abstract
Mesoporous silica nanoparticles with unique structure (SBA-15) were synthesized and modified by [3-(2-Aminoethylamino) propyl] trimethoxysilane (AEAPTMS). The synthesized nanoparticles were characterized by TGA, N‌2‌ adsorption, SEM, FTIR, CHN elemental analysis. The total weight loss for the modified SBA-15 is 15.2% and thermal analysis revealed that 1.5 mmol AEAPTMS/1g SBA-15 had been grafted. The modified particles were used as a drug delivery system. Ibuprofen as common nonsteroidal anti-inflammatory drugs was used to evaluate the controlled drug release properties of modified SBA-15.The results show that the modification of SBA-15 with organic groups such as [3-(2-Aminoethylamino) propyl] trimethoxysilane and (3-aminopropyl) triethoxysilane (APTES) improve the organophilicity of the SBA-15 and the drug loading efficiency. The results of drug delivery experiments reveal that the surface modification of SBA-15 with amino groups significantly decreases the drug delivery rate. The data obtained from the in vitro release studies was used to evaluate the kinetic mechanism of release; the initial 60% release of drug at pH 7.4 fits with the Korsmeyer – Peppas model, when diffusion is the main drug release mechanism.
Keywords
Drug delivery; Ibuprofen; Nano silica; SBA-15; Surface modification
Statistics
Article View: 2,129
PDF Download: 2,991
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Creative Commons
International Journal of Nanoscience and Nanotechnology is licensed under a
"Creative Commons Attribution 4.0 International (CC-BY 4.0)"

 

Journal Management System. Designed by sinaweb.