Iranian Nanotechnology Society International Journal of Nanoscience and Nanotechnology 1735-7004 21 2 2025 06 30 Laser-Assisted Synthesis and Modification of Nanodiamond/Gold Nanocomposites: A Novel Therapeutic Approach for Burn Wound Healing in Diabetic Rats 89 96 737970 10.22034/ijnn.2026.2050371.2624 EN Fariba Mehradnia Department of Atomic and Molecular Physics, Faculty of Physics, Alzahra University, Tehran, Iran BATOOL SAJAD Department of Atomic and Molecular Physics, Faculty of Physics, Alzahra University, Tehran, Iran Farideh Bahrami Department of Physiology and Medical Physics, Faculty of Medicine, Baqyatoolah University of Medical Sciences, Tehran, Iran Seyedeh Soraya Mousavi tehran Seyyed Ahad Bagheri Department of Physiology and Medical Physics, Faculty of Medicine, Baqyatoolah University of Medical Sciences, Tehran, Iran Seyyed Homayoun Sadraei Department of Anatomy, Faculty of Medicine, Baqyatoolah University of Medical Sciences, Tehran, Iran Javad Raouf Sarshoori Department of Anatomy٫Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran,Iran. Journal Article 2025 01 10 This study presents a novel laser-assisted method for synthesizing a nanocomposite of nanodiamonds (NDs) and gold nanoparticles (Au NPs). Our approach uniquely uses laser treatment to simultaneously create the nanocomposite and modify the ND structure, enhancing its biomedical properties.<br>We evaluated the therapeutic potential of this nanocomposite in diabetic wound healing studies using highly diabetic rat models, where it demonstrated superior efficacy compared to other treatments. Individual treatments with NDs and Au NPs significantly improved over the control group. higher wound closure rates by Day 7 compared to ND, AuNP, and control groups (p < 0.001). Re-epithelialization analysis on Day 21 confirmed superior regeneration in the ND/AuNP group versus all other groups (p < 0.001).<br>These results highlight the promise of our innovative synthesis strategy for advancing therapeutic applications in diabetic wound healing. https://www.ijnnonline.net/article_737970_3a30c8b30adfa6b672fec3a1d462b6d3.pdf