Iranian Nanotechnology Society International Journal of Nanoscience and Nanotechnology 1735-7004 19 2 2023 05 01 Screening Assessment of the Potential ‎Hazard of Nanomaterials using a Bull ‎Sperm 77 84 705088 10.22034/ijnn.2023.557252.2236 EN O. Demetska Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine 0000-0002-8174-7813 O. Beliuha State Institution «Kundiiev Institute of Occupational Health of the National Academy of ‎Medical Sciences of Ukraine», Kyiv, Ukraine 0000-0001-9445-9469 V. Movchan State Institution «Kundiiev Institute of Occupational Health of the National Academy of ‎Medical Sciences of Ukraine», Kyiv, Ukraine M. Didenko State Institution «Kundiiev Institute of Occupational Health of the National Academy of ‎Medical Sciences of Ukraine», Kyiv, Ukraine 0000-0002-6712-7976 V. Riabovol Bogomolets National Medical University, Kyiv, Ukraine 0000-0002-1582-7188 T. Patyka State Institution «Kundiiev Institute of Occupational Health of the National Academy of ‎Medical Sciences of Ukraine», Kyiv, Ukraine 0000-0003-1316-0516 V. Tsapko State Institution «Kundiiev Institute of Occupational Health of the National Academy of ‎Medical Sciences of Ukraine», Kyiv, Ukraine 0000-0001-8176-152X A. Balia Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan 0000-0002-1443-6572 Journal Article 2022 07 06 <em>   </em><em>This paper studied a potential hazard of titanium dioxide nanomaterials in the primary sreening methods on the sample of bull sperm.</em><em> </em><em>A method for stabilizing metal nanopowders and their derivatives for biomedical studies is proposed. It was found that the complex of titanium dioxide doped with silver (Ag-TiO2) and nanopowder of titanium dioxide (TiO2) at concentrations of 3 mg/ml initiate pathological changes in the bull sperm: the release of phospholipids as a result of the destruction of membranes and morphological abnormalities (abnormalities of the head, middle part, and tail, as well as the absence of acrosome, etc)</em><em>. T</em><em>he pathological effect of Ag-TiO2 nanocomposite </em><em>was</em><em> more pronounced. Doping with silver can increase the toxicity of nanotitanium dioxide, which requires further in-depth experimental studies using different concentrations by in vivo and in vitro methods.</em> https://www.ijnnonline.net/article_705088_7c49f90c2821ec5f210f66c8b6849dc4.pdf