Iranian Nanotechnology Society International Journal of Nanoscience and Nanotechnology 1735-7004 10 4 2014 12 01 Optimization of Iron Oxide Nanoparticle Preparation for Biomedical Applications by Using Box-Behenken Design 257 261 11237 EN S. Honary Honary P. Ebrahimi Department of Chemistry, Faculty of Sciences, Golestan University, P.O. Box 155, Post code 4913815759, Gorgan, I.R.Iran H. Asgari-rad Mazandaran University of Medical Sciences, School of Pharmacy, Department of Pharmacy, Sari, I.R.Iran F. Mohamadpour Mazandaran University of Medical Sciences, School of Pharmacy, Department of Pharmacy, Sari, I.R.Iran Journal Article 2013 06 03 Magnetic nanoparticles can bind to different drug delivery systems and can be used for drug targeting to a specific organ by using an external magnetic field as well as used in hyperthermia by heating in alternating magnetic fields. The characteristics of iron oxide nanoparticles are significantly affected by particle size, shape and zeta potential, among which the particle size plays the most important role. In this study, a chemometric approach was applied for the optimization of iron oxide nanoparticle size. To optimize the size of nanoparticles, the effect of three experimental parameters on size was investigated by means of multivariant analysis for which Fe 2+/Fe3+ ratio, pH and ionic strength of the media were considered. The experiments were performed on the basis of the Box-Behenken experimental design. The obtained regression model was characterized by both descriptive and predictive abilities (R2 = 1). The method was optimized with respect to Z average diameter as a response. The Box-Behenken experimental design provides optimality in optimizing and testing the robustness of iron oxide nanoparticles preparation method.

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