%0 Journal Article %T TiO2 Nanoparticles: A Potent ‎Heterogenous Nanocatalyst Mediated ‎One-Pot Tandem Approach for the ‎Environmentally Friendly Synthesis of 3,4-‎Dihydropyrimidin-2-(1H)-One/Thione ‎Derivatives Under Solvent-Free Conditions %J International Journal of Nanoscience and Nanotechnology %I Iranian Nanotechnology Society %Z 1735-7004 %A Mohamadpour, F. %D 2019 %\ 05/01/2019 %V 15 %N 2 %P 137-144 %! TiO2 Nanoparticles: A Potent ‎Heterogenous Nanocatalyst Mediated ‎One-Pot Tandem Approach for the ‎Environmentally Friendly Synthesis of 3,4-‎Dihydropyrimidin-2-(1H)-One/Thione ‎Derivatives Under Solvent-Free Conditions %K TiO2 Nanoparticles %K 3 %K 4-Dihydropyrimidin-2-(1H)-one/thione derivatives %K High atom-economy %K ‎Environment-friendly procedure %K Solvent-free conditions.‎ %R %X    This procedure has developed the use of TiO2 nanoparticles as an environmentally friendly and highly efficient heterogenous nanocatalyst for the eco-safe, facile and one-pot three-component Biginelli synthesis of biologically active corresponding 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives under solvent-free conditions. This eco-friendly protocol provides high to excellent yields, short reaction times, clean reaction, simplicity and easy work up and mild conditions compared to the traditional method of synthesis. Furthermore, environment-friendly, readily available, low-cost and non-toxic nanocatalyst made this protocol economic and sustainable. %U https://www.ijnnonline.net/article_35423_6f1a47af327694eae34d99fda0b1f06e.pdf