%0 Journal Article %T Different PVA-Hydroxypropyl Guar Gum Irradiated Nanosilica Composite Membranes for Model Drug Delivery Device %J International Journal of Nanoscience and Nanotechnology %I Iranian Nanotechnology Society %Z 1735-7004 %A Bhunia, T. %D 2018 %\ 08/01/2018 %V 14 %N 3 %P 187-195 %! Different PVA-Hydroxypropyl Guar Gum Irradiated Nanosilica Composite Membranes for Model Drug Delivery Device %K Polymer %K Irradiation %K Membrane %K Nanosilica and drug delivery %R %X    High strength and elastic biodegradable membranes are of great demand in modern technology. Similar membranes have been developed by irradiating different weight poly (vinyl alcohol) (PVA) – hydroxypropyl guar gum (HPG) blends and followed by combining with ex situ nanosilica. Polarized light microscopic (PLM) study indicates that electron beam irradiation produced crosslinks and developed crystallinity in PVA-HPG matrix. Atomic force microscopic analysis shows that 1 wt.% nanosilica produced finer dispersion in both high and low molecular weight PVA-HPG matrix resulting nearly 4.5 times higher mechanical strength and controlled swelling-deswelling property e.g., low molecular weight PVA with 1wt% nanosilica content show swelling ratio 3.5. Greater nanosilica and PVA-HPG interaction was observed in low molecular PVA-HPG composite membranes than high molecular weight PVA-HPG composite membranes which finally showed better efficacy towards drug retention and elution under physiological condition. %U https://www.ijnnonline.net/article_32218_e31fae49c184dd4d6afe82d1aed593d4.pdf