Document Type: Research Paper
Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
This procedure has developed the use of TiO2 nanoparticles as an environmentally friendly and highly efficient heterogenous nanocatalyst for the eco-safe, facile and one-pot three-component Biginelli synthesis of biologically active corresponding 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives under solvent-free conditions. This eco-friendly protocol provides high to excellent yields, short reaction times, clean reaction, simplicity and easy work up and mild conditions compared to the traditional method of synthesis. Furthermore, environment-friendly, readily available, low-cost and non-toxic nanocatalyst made this protocol economic and sustainable.