Document Type : Research Paper
Department of Chemistry, Pakokku University, Myaing Road, Pakokku 90401, Myanmar
Department of Chemistry, Airlangga University, Kampus C Mulyorejo, Surabaya 60115, Indonesia
Walchand Center for Research in Nanotechnology and Nanotechnology, WCAS Solapur University, Solapur, Maharashtra, India
Supramodification Nano-micro–Engineering Research Group, Universitas Airlangga, Surabaya 60115, Indonesia
Carbon dots (CDs) are a new type of QD that has attracted a great deal of attention in recent years because of their multiple fascinating characteristics and advantages resulting from physical and optical properties, fluorescence, water solubility, low toxicity, facile synthesis, favorable quantum yield, long thermal storage resistance and photostability. CDs offer promising applications in therapeutics, diagnostics, optoelectronic devices etc. In this review conjugation and composite formation at nanoscale level between CDs and other materials for altering their properties for the desired therapeutic uses are discussed. CD in order to be suitable for its application as a therapeutic agent it needs desired particle size, size distribution – as they affect the in-vivo distribution, stability, drug loading and drug release ability, uptake by cells, biological fate, toxicity, and targeting ability to a range of cellular and intracellular targets, easy mobility and capacity to cross the blood-brain barrier etc. Conjugating agents of biogenic origin, organic material, synthetic drugs and antibiotics as well as inorganic heteroatoms are discussed.