%0 Journal Article %T Synthesis of Three-Layered Magnetic Based Nanostructure for Clinical Application %J International Journal of Nanoscience and Nanotechnology %I Iranian Nanotechnology Society %Z 1735-7004 %A Khosroshahi, M. E. %A Ghazanfari, L. %D 2011 %\ 06/01/2011 %V 7 %N 2 %P 57-64 %! Synthesis of Three-Layered Magnetic Based Nanostructure for Clinical Application %K Multilayer nanostructure %K Magnetic Properties %K UV-Vis Spectroscopy %R %X The main objective of this research was to synthesize and characterize gold-coated Fe3O4 /SiO2 nanoshells for clinical applications. Magnetite nanoparticles (NPs) were prepared via co-precipitation. The results showed that smaller particles can be synthesized by decreasing the NaOH concentration, which in our case this corresponded to 35 nm by using 0.9 M of NaOH at 750 rpm. The NPs were then modified with a thin layer of silica using Stober method. The surface of Fe3O4 /SiO2 nanoshells was then terminated with amine groups with 3-aminopropyltriethoxysilane (APTS) in ethanol. Small gold colloid (1-3 nm) were adsorbed on the particle surface via the interaction between the negative charge on the Au nanoparticles and the positive charge of -NH3 on the SiO2 shell modified by APTS. Gold nanoshell formation, morphology and dimensions were assessed with a UV-Vis spectrophotometer, atomic force microscope (AFM), and transmission electron microscope (TEM). The synthesized nanostructures exhibited an absorption peak at ~550 nm with a magnetization value of 1.3 emu/g. Based on the X-ray diffraction (XRD) results, three main peaks of Au were identified. The formation of each layer of a nanoshell is also demonstrated by Fourier transform infrared (FTIR) results. %U https://www.ijnnonline.net/article_3941_238cb31aa941657e125c7e7b04e6cd0d.pdf