International Journal of Nanoscience and Nanotechnology

International Journal of Nanoscience and Nanotechnology

Nanotechnology in the Treatment of Infectious Diseases: A Review

Document Type : Research Paper

Authors
Aya Yaseen Mahmood Alabdali 1
Marwah Kzar 2
Sasikala Chinnappan 3
Ravishankar Ram Mani 3
Chung Kah Xin 3
Ivy Tiong Yien Ting 3
Lai Jing Yung 3
Patricia Lee Yee Wei 3
1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Mashreq, Baghdad, Iraq
2 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al Farahidi University, Baghdad, Iraq
3 Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, 56000, Malaysia
10.22034/ijnn.2023.531029.2056
Abstract
  The recent development of nanotechnology gradually become the trend of the world which has also revolutionized the pharmaceutical fields. Nanotechnology is the method used to produce nanoscale particles which can be applied in various aspects such as diagnostics and treatments. Meantime, an infectious disease also becomes a major cause of morbidity and mortality in humans nowadays. The small size of infectious disease agents has been a great concern in some of the diagnostics, preventions, and treatments are hard to achieve a desirable effect. In this way, nanotechnology becomes the key to the improvement of the pharmaceutical application’s performance for infectious diseases. Vaccination is one of the prevention methods to control the spread of infectious diseases. However, some vaccines lead to serious complications due to the difficulty of accessing and damaging infectious disease agents. By utilizing nanotechnology, vaccines delivered via lipid nanoparticles and viral-vectored vaccines are developed to improve the safety profile and the immune response of the vaccination. Besides prevention, nanotechnology also has been used in the drug delivery system and therapeutic drugs for infectious diseases. A nanoparticle-based drug delivery system can enhance the treatment outcome from various aspects such as the biocompatibility of the drug, the stability of the drug, and the capability of the drug in different drug delivery systems.
Keywords
Nanotechnology
Drug delivery System
Infectious diseases
Therapeutic drugs

Subjects

  1. Douglas, D. “Pharmaceutical Nanotechnology: A Therapeutic Revolution”, International Journal of Pharmaceutical Sciences and Developmental Research, 6(1) (2020) 009-011.
  2. Chakraborty, D., Kumar, S., Chandrasekaran, N., Mukherjee, A. “Viral Diagnostics and Preventive Techniques in the Era of COVID-19: Role of Nanoparticles”, Frontiers in Nanotechnology, 2 (2020) 1-7.
  3. Singh, L., Kruger, H. G., Maguire, G., Govender, T., Parboosing, R. “The role of nanotechnology in the treatment of viral infections”, Therapeutic advances in infectious disease.,4(4) (2017) 105–131.
  4. Rizvi, S. A., Saleh, A. M., “Applications of nanoparticle systems in drug delivery technology”, Saudi Pharmaceutical Journal, 26(1) (2018) 64-70.
  5. Sekhon, B.P, Saluja, V. “Nanovaccines-An overview”, International Journal of Pharmaceutical Frontier Research, 1(1) (2011) 101-109.
  6. Zaman, M., Good, M. F., Toth, I. “Nanovaccine and their mode of action”, Methods, 60(3) (2013) 226–231.
  7. Gheibi Hayat, S. M., Darroudi, M.. “Nanovaccine: A novel approach in immunization”, Journal of Cellular Physiology, 234(8) (2019) 12530–12536.
  8. Agarwal, M.., “Role of Nanovaccine in Immunotherapy”, J Cell Sci Ther., S8: 001 (2019) 1-9.
  9. Vijayan, V., Mohapatra, A., Uthaman, S., Park, I. K. “Recent advances in nanovaccines using biomimetic immunomodulatory materials”, Pharmaceutics, 11(10) (2019) 1-27.
  10. Singh, L., Kruger, H. G., Maguire, G., Govender, T., Parboosing, R. “The role of nanotechnology in the treatment of viral infections”, Therapeutic advances in infectious disease.,4(4) (2017) 105–131.
  11. Farjadian, F., Ghasemi, A., Gohari, O., Roointan, A., Karimi, M., Hamblin, M. “Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities”, Nanomedicine, 14(1) (2019) 93-126.
  12. Valentín, Cena., Pablo, Jativa. “Nanoparticle crossing of blood–brain barrier: a road to new therapeutic approaches to central nervous system diseases”, Nanomedicine, 13(13) (2018) 1513-1516.
  13. Andreas, Zumbuehl., Lino Ferreira, Duncan Kuhn., Anna, Astashkina., Lisa, Long., Yoon, Yeo., Tiffany, Iaconis., Mahmoud, Ghannoum., Gerald, R Fink., Robert Langer., Daniel, S Kohane. “Antifungal hydrogel”, PNAS, 104(32) (2007) 12994-12998.
  14. Peek, L.J., Middaugh, C.R., Berkland, C. “Nanotechnology in vaccine delivery”, Advanced Drug Delivery Review,  60(8) (2008) 915-928.
  15. Dutta, T., Garg, M., Jain, N.K. “Targeting of efavirenz loaded tuftsin conjugated poly(propyleneimine) dendrimers to HIV infected macrophages in vitro”, European Journal of Pharmaceutical Sciences., 34(2-3) (2008) 181-189. 
  16. Liu, M., Winters, M., Holodniy, Dai, H.J. “Carbon Nanotubes in Drug and Gene Delivery” Angewandte Chemie., 46 (2007) 2023–2027. 
  17. Chakravarty, M., Vora, A. “Nanotechnology-based antiviral therapeutics, Drug Delivery and Translational Research, 11 (2020)748–787.
  18. Munir, M., Ahmed, A., Usman, M.,Salman, S. “Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes”, International Journal of Nanomedicine, 15 (2020) 7329-7358.
  19. Rai, M., Ingle, A., Pandit, R., Paralikar, P., Gupta, I., Anasane, N., Dolenc-Voljč, M. “Nanotechnology for the Treatment of Fungal Infections on Human Skin”, The Microbiology of Skin, Soft Tissue, Bone and Joint Infections, (2017) 169-184.
  20. Aminu, Musa., Hajara Wada, Bawa., Ameen Hadi, Mohammed., and Aliyu Danmusa, Mohammed. “Green Synthesis of Silver Nanoparticles and Its Antibacterial Activity using the Flower Extract of Senna siamea”, J. Nanosci. Nanotechnol., 17(3) (2021) 173-179.
  21. Asmitha Beegum, S., and Begila David, S. “Investigation of Antimicrobial Activity of Plant-Mediated Green Synthesis of Silver Nanoparticles”, J. Nanosci. Nanotechnol., 18(4) (2022)265-274.
  22. Sandupatla, Raju., Dongamanti, Ashok., Ananda, Rao Boddu. “Leucaena Leucocephala Mediated Green Synthesis of Silver Nanoparticles and Their Antibacterial, Dye Degradation and Antioxidant Properties”, J. Nanosci. Nanotechnol., 18(1) (2022) 65-78.
International Journal of Nanoscience and Nanotechnology
Volume 19, Issue 1
Winter 2023
Pages 1-8