Selective Potentiometric Sensor for Isoniazid Ultra-Trace Determination Based on Fe3O4 Nanoparticles Modified Carbon Paste Electrode (Fe3O4/CPE)

Shabani, R.; Lakhaiy Rizi, Z.; Moosavi, R.

Selective Potentiometric Sensor for Isoniazid Ultra-Trace Determination Based on Fe3O4 Nanoparticles Modified Carbon Paste Electrode (Fe3O4/CPE)

Document Type : Research Paper

Authors

R. Shabani ¹

Z. Lakhaiy Rizi ¹

R. Moosavi ²

¹ Department of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran.

² Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran.

Abstract

Significant effects of magnetic iron oxide (Fe₃O₄) nanoparticles on the potentiometric behavior of carbon paste electrode for bio determination of Isoniazid aromatic drug (INH) were studied. The electrochemical performance of modified Fe₃O₄/CPE was investigated. The constructed Fe₃O₄/CPE showed high precision, sensitivity and selectivity, for successfully determination of ultra-trace concentration of INH samples. In this research, pH effects, optimal condition for electrode and interfering Ions, on electrode response were investigated. The best potential response for Fe₃O₄/CPE was obtained with electrode composition of 0.012 g magnetic NPs, 0.006 g silicon oil and 0.060 g graphite powder at pH 6.5 and showed such a low detection limit as 3.09×10⁻¹³ mol L⁻¹ INH.

Keywords

Isoniazid

Magnetic nanoparticles

Fe3O4/CPE

Potentiometric sensor